Acetic Anhydride → HCID 20396811, compound

Participants

Reaction Steps

A mixture of 1 g of 2,2-bis{4-[2-hydroxy-3-(8-β-hydroxyethyl-7,7,9,9-tetramethyl-2,4-dioxo-1,3,8-triazaspiro[4.5]dec-3-yl)propoxy]phenyl}propane (obtained as described in Example 18) and 20 g of acetic anhydride was refluxed for 60 hours. After completion of the reaction, the reaction mixture was poured into ammoniacal ice-water, extracted with benzene and then purified by column chromatography through silica gel eluted with a 2:1 by volume mixture of benzene and ethyl acetate, to give the desired Compound No. 188 in the form of white crystals. The compound had an Rf value of 0.86 on thin-layer chromatography on silica gel using a 1:1:1 by volume mixture of n-hexane, benzene and ethyl acetate as developing solvent.

Provenance & Evidence