反应详情

A mixture of 8 g of 7,7,8,9,9-pentamethyl-1,3,8-triazaspiro[4.5]decane-2,4-dione and 5 g of 2,2-bis[4-(2,3-epoxypropoxy)cyclohexyl]propane was heated at 180°-200° C. for 5 hours. The reaction mixture was then purified by column chromatography through silica gel eluted with a 60:10:1 by volume mixture of ethyl acetate, ethanol and triethylamine and then by recrystallisation from ethyl acetate, giving the desired compound in the form of white crystals melting at 130°-133° C.

1. temperaturewas heated at 180°-200° C. for 5 hours
2. customThe reaction mixture was then purified by column chromatography through silica gel
3. washeluted with a 60:10:1 by volume mixture of ethyl acetate, ethanol and triethylamine
4. customby recrystallisation from ethyl acetate