Acetone → HCID 86734724, compound

Participants

Reaction Steps

Sodium (0.05 g, 0.02 m) is dissolved in dry acetone and 3.0 grams (0.01 m) of 1,6-bis(guanidino)hexane sulfate is added. The resulting suspension is stirred for two hours at room temperature and thereafter 3.4 grams (0.02 m) of 4-chlorophenyl isothiocyanate is added. The mixture is heated at 60° for three hours, then stirred overnight at room temperature. Ten milliliters of methanol are added to decompose residual sodium. The solvent is distilled and the residue is washed by decantation with several portions of water to leave the product as the free base. The residue is dissolved in 60 ml. of warm acetic acid. The solution is cooled and the diacetate which precipitates is collected on a filter, washed with acetic acid, then recrystallized from acetic acid, M.P. 145°-148° C.

Provenance & Evidence