Acetic Anhydride → N-Hexyl-N-(3-methyl-1,2,4-oxadiazol-5-yl)acetamide

Participants

Reaction Steps

5-n-Hexylamino-3-methyl-1,2,4-oxadiazole (4.6 g, 0.025 mole) was dissolved in acetic anhydride (25 ml) and refluxed for 3 hours and then evaporated down to dryness under vacuum. The residue was taken up in CHCl3 (50 ml) and washed twice with 2N HCl and twice with a saturated solution of NaHCO3 and dried over MgSO4. (b.p. 113°-114° C./1.0 mmHg.).

Provenance & Evidence