HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonium Hydroxide → 3-Phenethyl-5-methyl-isoxazole-4-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonium Hydroxide | HCID 14923 | — |
| Reactant | 5-Methyl-3-phenethylisoxazole-4-carbonyl chloride | HCID 53741949 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | 3-Phenethyl-5-methyl-isoxazole-4-carboxamide | HCID 20396494 | — |
Reaction Steps
A mixture of 24.9 g. (0.10 mole) 3-phenethyl-5-methyl-isoxazole-4-carboxylic acid chloride in 100 ml. diethyl ether is added to 7.7 g. (0.2 mole) of concentrated ammonium hydroxide while maintaining the temperature at 0° to 10° C. The mixture is stirred at room temperature overnight and filtered. The resulting solid is washed with water and dried to give 3-phenethyl-5-methyl-isoxazole-4-carboxamide; m.p. 135° to 136° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04163057 |
| Source dataset | uspto-grants-1979_07 |
| ORD ID | ord-255225866e6e4a2f8685992180733475 |
| Source note | uspto-grants-1979_07 |