HuagongsheHuagongshe Chemistry Print Report · For research reference only
Formaldehyde → 3-(Hydroxymethyl)phenytoin
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Formaldehyde | HCID 712 | — |
| Reactant | 5,5-Diphenylhydantoin | HCID 1775 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Solvent | Water | HCID 962 | — |
| Product | 3-(Hydroxymethyl)phenytoin | HCID 161366 | — |
Reaction Steps
20 g of 5,5-diphenylhydantoin (0.08 moles) and 80 ml (32 g) of formalin are introduced into a suitable reaction vessel containing 720 ml of water and one g of potassium carbonate. The reaction is stirred at room temperature for 24 hours, after which the subject compound, mp 186.5°-188.5° C., yield 22.58 g (91.86%) is obtained by filtration.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04163058 |
| Source dataset | uspto-grants-1979_07 |
| ORD ID | ord-cf2d76f527284f3cbacb2000501b9e3a |
| Source note | uspto-grants-1979_07 |