Formic Acid → HCID 54072220, compound

HRID 972083Notes

Reaction equation

HRID 972083 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][N:9]=[CH:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[CH:4][CH:3]=1.[CH:17](O)=[O:18].C(OC(=O)C)(=O)C>COCCOC>[CH:17]([N:8]([C:5]1[CH:4]=[CH:3][C:2]([Cl:1])=[CH:7][CH:6]=1)[N:9]=[CH:10][C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1)=[O:18]

Participants

5

Reactant 3

HCID 284Formic AcidHCID 7918Acetic AnhydrideHCID 3370184HCID 3370184, compound

Product 1

HCID 54072220HCID 54072220, compound

Reagents, catalysts & solvents 1

HCID 80711,2-DimethoxyethaneSolvent

Procedure

6.91 g of 1A was dissolved in 37.5 ml of dry 1,2-dimethoxyethane and treated with 4.5 g of distilled mixed anhydride of formic acid and acetic acid prepared by mixing the appropriate amount of formic acid and acetic anhydride. The resulting mixture was left for 4 hours at room temperature and then heated up to boiling point and excess solvent removed in vacuo. The residue was triturated with 5% sodium bicarbonate solution, dried and crystallized from methanol to give 1, mp 122°-123° C.

Workup

  1. additiontreated with 4.5 g
  2. distillationof distilled
  3. additionmixed anhydride of formic acid and acetic acid
  4. customprepared
  5. temperatureheated up
  6. customremoved in vacuo
  7. customThe residue was triturated with 5% sodium bicarbonate solution
  8. customdried
  9. customcrystallized from methanol
  10. customto give 1, mp 122°-123° C.

Sources & evidence

ORD record
ord-ab69fd9438a8499f83ba9a1979c8d968
Source dataset
uspto-grants-1979_07
Patent number
US04163062

Reaction notes

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