N-(2-benzoyl-4-chlorophenyl)-methyl-hydrazinecarbothioamide → 7-Chloro-3-methyl-5-phenyl-2-thioxo-1,2-dihydro-3H-1,3,4-benzotriazepine

Participants

Reaction Steps

A mixture containing 20.0 grams of N-(2-benzoyl-4-chlorophenyl)-methyl-hydrazine-carbothioamide (Example 2) in 250 ml of n-propanol was refluxed for about 2 hours. The mixture was cooled in an ice bath, and the resulting yellow precipitate was collected, washed with isopropanol, and air dried to yield 7-chloro-1,3-dihydro-3-methyl-5-phenyl-2H-1,3,4-benzotriazepine-2-thione as a yellow solid. Additional product was obtained upon evaporation of the solvent under vacuum. The melting point was found to be 188°-190° C.

Provenance & Evidence