HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl iodide → 7-Nitro-4-methyl-4H-benzo[1,4]thiazin-3-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 7-Nitro-2H-benzo[b][1,4]thiazin-3(4H)-one | HCID 370121 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 7-Nitro-4-methyl-4H-benzo[1,4]thiazin-3-one | HCID 21877780 | — |
Reaction Steps
7.3 g 7-Nitro-4H-benzo[1,4]thiazin-3-one was suspended in 65 ml DMF and treated in portions with 1.6 g of 55% sodium hydride. Stirring a room temperature was continued for 0.5 hrs, than 5.2 g methyl iodide in 15 ml DMF were added dropwise. After another 3 hrs the mixture was poured into ice water and the title product isolated by filtration in a yield of 7.5 g.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07091345B2 |
| Source dataset | uspto-grants-2006_08 |
| ORD ID | ord-0de7095bd6ab45469c4e0d001ceb86a0 |
| Source note | uspto-grants-2006_08 |