Methanol → HCID 22794520, compound

Participants

Reaction Steps

The 350 g of the L-lysine L-glutamate dihydrate, α-phase, previously prepared, still containing approximately 15% by weight of methanol, are suspended in 0.85 liter of n-amyl alcohol in a nitrogen atmosphere. The n-amyl alcohol is then heated, followed by the distillation at around 70° first of a ternary mixture containing n-amyl alcohol, methanol and water (approximately 0.1 liter) and then of a binary mixture of n-amyl alcohol and water (approximately 0.1 liter). Heating is terminated at the reflux temperature of the n-amyl alcohol i.e. at 138° C. After a total heating time of 20 hours, the precipitate formed is separated by filtration. This gives 400 g of crude product containing ε-(γ-L-glutamyl)-L-lysine and approximately 1 liter of amylic mother liquors from which 20 g of L-pyroglutamic acid are recovered from recycling after conversion into L-glutamic acid. The n-amyl alcohol is purified for recycling.

Provenance & Evidence