HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanethiol → 4-(Methylthio)pyrazolo[1,5-a]quinoxaline-3-carboxylic acid, ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanethiol | HCID 878 | — |
| Reactant | Water | HCID 962 | — |
| Reactant | Sodium | HCID 5360545 | — |
| Reactant | Ethyl 4-chloropyrazolo[1,5-A]quinoxaline-3-carboxylate | HCID 54256020 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 4-(Methylthio)pyrazolo[1,5-a]quinoxaline-3-carboxylic acid, ethyl ester | HCID 85921480 | — |
Reaction Steps
2.76 g. of 4-chloropyrazolo[1,5-a]quinoxaline-3-carboxylic acid ethyl ester are heated with 0.71 g. of the sodium salt of methyl mercaptan in dimethylformamide. After cooling, the reaction mixture is poured into water. The product 4-(methylthio)pyrazolo[1,5-a]quinoxaline-3-carboxylic acid, ethyl ester is filtered under suction and crystallized from ethanol as white needles, m.p. 97°-98°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04052393 |
| Source dataset | uspto-grants-1977_10 |
| ORD ID | ord-233a6897f18f4f138a0f07bfc540624c |
| Source note | uspto-grants-1977_10 |