Bromine → HCID 21406310, compound

HRID 972201Notes

Reaction equation

HRID 972201 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([C:10]2[CH2:11][CH2:12][C:13](=[O:16])[NH:14][N:15]=2)[CH:5]=[C:6]([Cl:9])[C:7]=1[CH3:8].BrBr>C(O)(=O)C>[Br:1][C:2]1[CH:3]=[C:4]([C:10]2[CH:11]=[CH:12][C:13](=[O:16])[NH:14][N:15]=2)[CH:5]=[C:6]([Cl:9])[C:7]=1[CH3:8]

Participants

4

Reactant 2

HCID 24408BromineHCID 21406359HCID 21406359, compound

Product 1

HCID 21406310HCID 21406310, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

3 In acetic acid heated to 70° C. was suspended 6.3 g. of 6-(3-bromo-5-chloro-4-methylphenyl)-4,5-dihydro-3(2H)pyridazinone, and to this suspension was added dropwise with stirring 3.7 g. of bromine. After completion of the addition, the reaction mixture was treated in the manner as in Example 1 - 3 to give 6.2 g. of the desired product of m.p. 247° - 250° C.

Workup

  1. additionAfter completion of the addition
  2. additionthe reaction mixture was treated in the manner as in Example 1 - 3
  3. customto give 6.2 g

Sources & evidence

ORD record
ord-fafe88605f174a03aaaa71411feada0a
Source dataset
uspto-grants-1977_10
Patent number
US04052395

Reaction notes

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