Dimethylformamide → HCID 21406361, compound

Participants

Reaction Conditions

Reaction Steps

To a mixture of 4.9 g. of 6-(3,5-dichloro-4-hydroxyphenyl)-3-(2H)pyridazinone obtained in Example 5 and 2 g. of triethylamine in 30 ml. of dimethylformamide was added dropwise 2.4 g. of allyl bromide at 50° C. while stirring. The mixture was stirred at 50° C. for further 5 hours. After cooling, the reaction mixture was poured into 200 ml. of water and allowed to stand for a while. White solid substance thus formed was recovered by filtration, washed with water, dried to give 3.6 g. of crude crystalline substance, which was then recrystallized from methanol to give 3.2 g. of the desired product as colorless needles of m.p. 214° - 215° C.

Provenance & Evidence