Acetic Anhydride → HCID 21406318, compound

HRID 972207Notes

Reaction equation

HRID 972207 reaction equation
[Br:1][C:2]1[C:3]([OH:17])=[C:4]([C:10]2[CH:11]=[CH:12][C:13](=[O:16])[NH:14][N:15]=2)[CH:5]=[C:6]([Br:9])[C:7]=1[CH3:8].[C:18](OC(=O)C)(=[O:20])[CH3:19]>C1C=CC=CC=1>[C:18]([O:17][C:3]1[C:2]([Br:1])=[C:7]([CH3:8])[C:6]([Br:9])=[CH:5][C:4]=1[C:10]1[CH:11]=[CH:12][C:13](=[O:16])[NH:14][N:15]=1)(=[O:20])[CH3:19]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 13627389662902-45-8

Product 1

HCID 21406318HCID 21406318, compoundYield 71.5%

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

A mixture of 1.0 g. of 6-(3,5-dibromo-2-hydroxy-4-methylphenyl)-3-(2H)pyridazinone and 2 ml. of acetic anhydride in 10 ml. of benzene was heated under reflux for 3 hours. After cooling, the so separated crystalline substance was recovered by filtration and dried to give 0.8 g. of the desired product as yellow needles of m.p. 220° C. (Yield 71.5%).

Workup

  1. additionA mixture of 1.0 g
  2. temperatureunder reflux for 3 hours
  3. temperatureAfter cooling
  4. filtrationthe so separated crystalline substance was recovered by filtration
  5. customdried
  6. customto give 0.8 g

Sources & evidence

ORD record
ord-6b325ba319214b5088613f095aa73d09
Source dataset
uspto-grants-1977_10
Patent number
US04052395

Reaction notes

Loading…