Methyl Isocyanate → HCID 21406321, compound

HRID 972210Notes

Reaction equation

HRID 972210 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:10]2[CH:11]=[CH:12][C:13](=[O:16])[NH:14][N:15]=2)[CH:5]=[C:6]([Cl:9])[C:7]=1[CH3:8].O1CCOCC1.[CH3:23][N:24]=[C:25]=[O:26]>CCCCCC>[CH3:23][N:24]=[C:25]=[O:26].[Cl:1][C:2]1[CH:3]=[C:4]([C:10]2[CH:11]=[CH:12][C:13](=[O:16])[NH:14][N:15]=2)[CH:5]=[C:6]([Cl:9])[C:7]=1[CH3:8]

Participants

5

Reactant 3

HCID 12228Methyl IsocyanateHCID 312751,4-DioxaneHCID 93341Diclomezine

Product 1

HCID 21406321HCID 21406321, compoundYield 82%

Reagents, catalysts & solvents 1

HCID 8058HexaneSolvent

Procedure

To a hot solution of 1.0 g. of 6-(3,5-dichloro-4-methylphenyl)-3(2H)pyridazinone in 25 ml. of dioxane was added an excess molar amount (above 0.5 ml.) of methyl isocyanate and the mixture in a sealed vessel was allowed to stand at room temperature for 3 hours. Then, 5 ml. of n-hexane was added and the resulting mixture was cooled to give 1.0 g. of the desired product as needles of m.p. ca. 250° C. (with decomp.) (Yield 82%).

Workup

  1. customthe mixture in a sealed vessel was allowed
  2. temperaturethe resulting mixture was cooled
  3. customto give 1.0 g

Sources & evidence

ORD record
ord-ed31cd9958464dc3a234466bedfe5b7d
Source dataset
uspto-grants-1977_10
Patent number
US04052395

Reaction notes

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