Sulfuric Acid → HCID 21406503, compound

HRID 972255Notes

Reaction equation

HRID 972255 reaction equation
[CH3:1][C:2](O)([C:6]1[CH:18]=[CH:17][C:16]2[C:15]3[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=3)[CH2:9][C:8]=2[CH:7]=1)[C:3]([OH:5])=[O:4].S(=O)(=O)(O)O>O1CCOCC1>[CH2:1]=[C:2]([C:6]1[CH:18]=[CH:17][C:16]2[C:15]3[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=3)[CH2:9][C:8]=2[CH:7]=1)[C:3]([OH:5])=[O:4]

Participants

4

Reactant 2

HCID 1118Sulfuric AcidHCID 11184364HCID 11184364, compound

Product 1

HCID 21406503HCID 21406503, compoundYield 98.2%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A solution of α-methyl-α-hydroxyfluorene-2-acetic acid (5.7 g) and sulfuric acid (11.4 ml) in dioxane (300 ml) is refluxed for 2 hours. The reaction mixture is poured into ice water and extracted with ether. The ether extracts are washed with water, dried (MgSO4), and evaporated to give the title compound (5.2 g, mp 183°-185°). The analytical sample is prepared by recrystallization from 95% ethanol, mp 190°-191°, λKBr 880 cm-1.

Workup

  1. extractionextracted with ether
  2. washThe ether extracts are washed with water
  3. dry with materialdried (MgSO4)
  4. customevaporated

Sources & evidence

ORD record
ord-c46a42b2b6f24465a57dac1b636fc002
Source dataset
uspto-grants-1977_10
Patent number
US04052436

Reaction notes

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