Sodium Hydroxide → HCID 21406751, compound

Participants

Reaction Steps

The ester (650 mg.) was mixed with water (5 ml.), industrial methylated spirits (IMS) (5 ml.) and aqueous sodium hydroxide (0.4 ml; 18N), and refluxed for 1 hour. IMS was distilled and the residue acidified with dilute hydrochloric acid. The precipitate was filtered, washed with water, dried and recrystallised from 80-100 petroleum ether to give colourless needle clusters of 2,2',4'-trifluoro-4-biphenylylacetic acid having a m.p. of 145°-147° C.

Provenance & Evidence