Methanol → HCID 54182122, compound

Participants

Reaction Steps

A solution of 2,2',4'-trifluoro-4-biphenylyl acetic acid (10 g.) in anhydrous methanol (100 ml.) and concentrated sulphuric acid (5 ml.) was refluxed overnight. Excess solvent was distilled and the residue was poured onto ice-water and extracted with ether. The extracts were washed with dilute aqueous sodium bicarbonate and then dried, evaporated and distilled to give a yellow oil, b.p. 142°-146°/0.5 mm., which solidified on cooling. This was crystallized from 62-68 petroleum ether to give methyl 2,2',4'-trifluoro-4-biphenylylacetate, m.p. 74°-77° C.

Provenance & Evidence