Morpholine → 1H-Benzimidazole, 2-(1-methyl-5-nitro-1H-imidazol-2-yl)-1-(2-(4-morpholinyl)ethyl)-

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Reaction Steps

0.31 g. of 1-(2-chloroethyl)-2-(5-nitro-1-methyl-2-imidazolyl)-benzimidazole are boiled for 12 hours with 0.18 g. of morpholine in 50 ml. of dioxane. By evaporation and preparative thin-layer chromatography of the mixture, 50 mg. of 1-(2-morpholinoethyl)-2-(5-nitro-1-methyl-2-imidazolyl)-benzimidazole is obtained, the hydrochloride of which has a melting point of 237° C.

Provenance & Evidence