HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 2-(5-Nitro-1-methyl-2-imidazolyl)-benzimidazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | O-Phenylenediamine | HCID 7243 | — |
| Reactant | 1-Methyl-5-nitro-1H-imidazole-2-carboxylic acid | HCID 15658229 | — |
| Product | 2-(5-Nitro-1-methyl-2-imidazolyl)-benzimidazole | HCID 21404692 | — |
Reaction Steps
1.7 g. of 5-nitro-1-methyl-2-imidazolyl carboxylic acid and 1.08 g. of o-phenylenediamine are heated for 40 minutes in a bomb tube to 180° C. in 10 ml. of 25% hydrochloric acid. After evaporating the reaction mixture to dryness and column chromatography on 100 g. of silica gel with methanol-chloroform 1 : 1, 120 mg. of 2-(5-nitro-1-methyl-2-imidazolyl)-benzimidazole is obtained, m.p. 257° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04053472 |
| Source dataset | uspto-grants-1977_10 |
| ORD ID | ord-61e2f8bfd10742faab33b8ceee7a54ee |
| Source note | uspto-grants-1977_10 |