Ammonia → HCID 21404764, compound

Participants

Reaction Steps

A solution of 0.04 part of N,N-dimethyl-N-(2-[5,6,7,8-tetrahydro-8-hydroxy-3-methoxyisoquinol-8-yl]prop-2-en-1-yl)amine and 0.5 part by volume of concentrated sulfuric acid is allowed to stand at room temperature for about 30 minutes. Then the reaction mixture is added to water and basified with aqueous ammonia. The solution is extracted with ether and the ethereal extracts are washed with saturated sodium chloride solution, dried over anhydrous sodium sulfate and evaporated under reduced pressure to yield N,N-dimethyl-N-(2-[5,6-dihydro-3-methoxyisoquinol-8-yl]prop-2-en-1-yl)amine, identical to the product of Example 16A.

Provenance & Evidence