HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzoyl isocyanate → 1-Benzoyl-3-(4,5,6,7-tetrahydrobenzo-[b]thien-4-yl)urea
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzoyl isocyanate | HCID 78210 | — |
| Reactant | 4,5,6,7-Tetrahydro-1-benzothiophen-4-amine | HCID 4216372 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 1-Benzoyl-3-(4,5,6,7-tetrahydrobenzo-[b]thien-4-yl)urea | HCID 13037006 | — |
Reaction Steps
A solution of benzoyl isocyanate (2.94g) in methylene chloride (5ml) is added to a solution of 4,5,6,7-tetrahydrobenzo[b]thiophen-4-amine is methylene chloride (50ml) under a nitrogen atmosphere. After stirring overnight at room temperature, the reaction mixture is evaporated to dryness in vacuo. The residue is then stirred in ether (100ml) and filtered to afford 1-benzoyl-3-(4,5,6,7-tetrahydrobenzo-[b]thien-4-yl)urea, m.p. 189° to 194° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04053484 |
| Source dataset | uspto-grants-1977_10 |
| ORD ID | ord-6f1c53c917f4403d94bc765740b6d833 |
| Source note | uspto-grants-1977_10 |