HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzoyl isocyanate → 1-Benzoyl-3-(4,5,6,7-tetrahydro-7-oxobenzo[b]-thien-4-yl)urea
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzoyl isocyanate | HCID 78210 | — |
| Reactant | 4-Amino-5,6-dihydro-1-benzothiophen-7(4H)-one | HCID 23347796 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 1-Benzoyl-3-(4,5,6,7-tetrahydro-7-oxobenzo[b]-thien-4-yl)urea | HCID 13037014 | 38.1% |
Reaction Steps
A solution of 4,5,6,7-tetrahydro-7-oxobenzo[b]thiophen-4-amine (8.02 g) in methylene chloride (75 ml) is added to a stirred solution of benzoyl isocyanate (7.0 g) in methylene chloride (75 ml) under a nitrogen atmosphere. The mixture is stirred for an overnight period at room temperature and the title compound is collected by filtration. Recrystallization of the crude product from acetone/hexane affords 5.7 g of the title compound, m.p. 204° to 207° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04053484 |
| Source dataset | uspto-grants-1977_10 |
| ORD ID | ord-4045cbfe73d545d29700172d25defd8e |
| Source note | uspto-grants-1977_10 |