HCID 10497707, compound → Glyphosate

Participants

Reaction Conditions

Reaction Steps

1,3,5-Tricarbethoxymethylhexahydro-1,3,5-triazine (5.76 parts) and di(4-methoxyphenyl)phosphite (15.3 parts containing 0.6 parts of 4-methoxyphenol) were mixed and heated to 80° C. for from 1/2 to 1 hour. Nuclear magnetic resonance spectral analysis indicated that a complete conversion to the ethyl N-[di(4-methoxyphenoxy)-phosphonomethyl]glycinate was obtained. The reaction mixture can then be diluted with 2 normal hydrochloric acid (225 ml) and heated to reflux for 2 hours. This reaction mixture is concentrated and then mixed with a mixture of water and methylene chloride. The water layer is then extracted with methylene chloride. The aqueous layer is concentrated to yield N-phosphonomethyl glycine.

Provenance & Evidence