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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 972580Generated: October 29, 2026

Sodium → 2-(3-Phthalimidopropylthio)pyrimidine

https://huagongshe.com/reaction/972580

Reaction equation

Participants

RoleNameHCIDCharge
ReactantSodiumHCID 5360545—
ReactantWater ethanolHCID 19096565—
ReactantBromopropylphthalimideHCID 21958088—
ReactantHCID 178418793HCID 178418793—
SolventEthanolHCID 702—
Product2-(3-Phthalimidopropylthio)pyrimidineHCID 3462547—

Reaction Steps

A mixture of 2-mercaptopyrimidine (5.6 g.) and 3-bromopropylphthalimide (13.4 g.) in ethanol (100 ml.) containing sodium (1.15 g.) was heated under reflux for 20 hours affording 2-(3-phthalimidopropylthio)pyrimidine, m.p. 81.5°-82.5° (from ethanol-water).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04053473
Source datasetuspto-grants-1977_10
ORD IDord-4728c14e328944c4be2d047482709bc0
Source noteuspto-grants-1977_10