(2-Isothiocyanatoethyl)dimethylamine → N-(2-Dimethylaminoethyl)-N'-[2-(2-pyrimidylmethylamino)ethyl]thiourea

HRID 972594Notes

Reaction equation

HRID 972594 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[N:3][C:2]=1[CH2:7][NH:8][CH2:9][CH2:10][NH2:11].[CH3:12][N:13]([CH3:19])[CH2:14][CH2:15][N:16]=[C:17]=[S:18]>>[CH3:12][N:13]([CH3:19])[CH2:14][CH2:15][NH:16][C:17]([NH:11][CH2:10][CH2:9][NH:8][CH2:7][C:2]1[N:3]=[CH:4][CH:5]=[CH:6][N:1]=1)=[S:18]

Participants

3

Reactant 2

HCID 3853726(2-Isothiocyanatoethyl)dimethylamineHCID 20557649N-(2-pyrimidylmethyl)ethylenediamine

Product 1

HCID 20557883N-(2-Dimethylaminoethyl)-N'-[2-(2-pyrimidylmethylamino)ethyl]thiourea

Procedure

Treating N-(2-pyrimidylmethyl)ethylenediamine with 2-dimethylaminoethyl isothiocyanate, then concentrating and separating by column chromatography by the procedure of Example 40(a)(ii) gives the title compound.

Workup

  1. concentrationconcentrating
  2. customseparating by column chromatography by the procedure of Example 40(a)(ii)

Sources & evidence

ORD record
ord-2b5d19c593ea4647a221e1126553ef87
Source dataset
uspto-grants-1977_10
Patent number
US04053473

Reaction notes

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