Methyl Isocyanate → N-Methyl-N'-[2-((4-methyl-5-oxazolyl)methylthio)ethyl]urea

HRID 972615Notes

Reaction equation

[NH2:1][CH2:2][CH2:3][S:4][CH2:5][C:6]1[O:10][CH:9]=[N:8][C:7]=1[CH3:11].[CH3:12][N:13]=[C:14]=[O:15]>>[CH3:12][NH:13][C:14]([NH:1][CH2:2][CH2:3][S:4][CH2:5][C:6]1[O:10][CH:9]=[N:8][C:7]=1[CH3:11])=[O:15]

Participants

Reactant 2

HCID 12228Methyl Isocyanate

HCID 125438634-Methyl-5-[(2-aminoethyl)thiomethyl]oxazole

Product 1

HCID 20557620N-Methyl-N'-[2-((4-methyl-5-oxazolyl)methylthio)ethyl]urea

Procedure

Reacting 5-[(2-aminoethyl)thiomethyl]-4-methyloxazole with methyl isocyanate by the procedure of Example 24 gives the title compound.

Sources & evidence

ORD record: ord-aa3e04231dca4dcc87bce8353ce35813
Source dataset: uspto-grants-1977_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04053473

Reaction notes

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