HuagongsheHuagongshe Chemistry Print Report · For research reference only
Salicylaldehyde → 2-[3-(Dimethylamino)propoxy]benzaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Salicylaldehyde | HCID 6998 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 3-Chloro-N,N-dimethyl-1-propanamine | HCID 66960 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 2-[3-(Dimethylamino)propoxy]benzaldehyde | HCID 2995968 | 77% |
Reaction Steps
The reaction between 100 g (0.82 mole) of salicylaldehyde, 40 g (0.82 mole) of 50% NaH, and 650 ml (1.2 mole) of 1.89 N 3-dimethylaminopropyl chloride in toluene in a procedure described in Example 2, part A, gives 130.4 g (77%) of yellow product, bp 125°-130°/0.5 mm.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04053514 |
| Source dataset | uspto-grants-1977_10 |
| ORD ID | ord-1611a928e5804cf4ba03b4e2f8b6fdbe |
| Source note | uspto-grants-1977_10 |