HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyanoacetamide → Piperidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyanoacetamide | HCID 7898 | — |
| Reactant | Ethyl formate | HCID 8025 | — |
| Reactant | Sodium | HCID 5360545 | — |
| Reactant | Sodium Methoxide | HCID 10942334 | — |
| Reactant | p-(4-Propyl-1-piperazinyl)acetophenone | HCID 21404502 | — |
| Reactant | p-(4-Propyl-1-piperazinyl)benzoylacetaldehyde | HCID 54256791 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | Piperidine | HCID 8082 | — |
| Product | 6-[p-(4-Propyl-1-piperazinyl)phenyl]-1,2-dihydro-2-oxonicotinonitrile | HCID 21404489 | — |
Reaction Steps
From a solution of the sodium salt of p-(4-propyl-1-piperazinyl)benzoylacetaldehyde in 150 ml. of water (prepared from 5.7 g. of sodium methoxide in 500 ml. of tetrahydrofuran, and a solution of 24.6 g. of p-(4-propyl-1-piperazinyl)acetophenone and 8.0 ml. of ethyl formate in 100 ml. of tetrahydrofuran), 8.4 g. of 2-cyanoacetamide and a solution consisting of 0.95 ml. of acetic acid, 4.0 ml. of water and 0.9 ml. of piperidine, there is obtained 6-[p-(4-propyl-1-piperazinyl)phenyl]-1,2-dihydro-2-oxonicotinonitrile; m.p. 288°-290° (dec.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04053470 |
| Source dataset | uspto-grants-1977_10 |
| ORD ID | ord-701e0f5809e84b688f4274a306826e0d |
| Source note | uspto-grants-1977_10 |