Cyanoacetamide → Piperidine

Participants

Reaction Steps

From a solution of the sodium salt of p-(piperidino)benzoylacetaldehyde in 300 ml. of water (prepared from 11.4 g. of sodium methoxide in 100 ml. of tetrahydrofuran, and a solution of 36.5 g. of p-(piperidino)acetophenone and 13.3 g. of ethyl formate in 130 ml. of tetrahydrofuran), 18.9 g. of 2-cyanoacetamide and a solution consisting of 2.3 ml. of acetic acid, 5.3 ml. of ester and 4.1 ml. of piperidine, there is obtained 6-(p-piperidinophenyl)-1,2-dihydro-2-oxonicotinonitrile.

Provenance & Evidence