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1-Cyclohexylpiperazine → 6-[p-(4-Cyclohexyl-1-piperazinyl)phenyl]-1,2-dihydro-2-oxonicotinonitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-Cyclohexylpiperazine | HCID 87298 | — |
| 反応物 | 6-(4-Fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carbonitrile | HCID 2765203 | — |
| 溶媒 | Dimethyl Sulfoxide | HCID 679 | — |
| 生成物 | 6-[p-(4-Cyclohexyl-1-piperazinyl)phenyl]-1,2-dihydro-2-oxonicotinonitrile | HCID 21404617 | — |
反応手順
From 11.7 g. of 6-(p-fluorophenyl)-1,2-dihydro-2-oxonicotinonitrile and 18.4 g. of N-cyclohexylpiperazine in 150 ml. of dimethyl sulfoxide, there is obtained 6-[p-(4-cyclohexyl-1-piperazinyl)phenyl]-1,2-dihydro-2-oxonicotinontrile; m.p. 306°-312° (dec.).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04053470 |
| 出典データセット | uspto-grants-1977_10 |
| ORD ID | ord-1a7f9d41dd45453ea612dff86a5e3ebb |
| 出典メモ | uspto-grants-1977_10 |