HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(1-Pyrrolidinyl)piperidine → 6-[p-[4-(1-Pyrrolidinyl)piperidino]phenyl]-1,2-dihydro-2-oxonicotinonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(1-Pyrrolidinyl)piperidine | HCID 78703 | — |
| Reactant | 6-(4-Fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carbonitrile | HCID 2765203 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | 6-[p-[4-(1-Pyrrolidinyl)piperidino]phenyl]-1,2-dihydro-2-oxonicotinonitrile | HCID 21404523 | — |
Reaction Steps
From 11.7 g. of 6-(p-fluorophenyl)-1,2-dihydro-2-oxonicotinonitrile and 16.7 g. of 4-(1-pyrrolidinyl)piperidine in 150 ml. of dimethyl sulfoxide, there is obtained 6-[p-[4-(1-pyrrolidinyl)piperidino]phenyl]-1,2-dihydro-2-oxonicotinonitrile; m.p. 318°-326° (dec.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04053470 |
| Source dataset | uspto-grants-1977_10 |
| ORD ID | ord-9da67b4fb1b845de9b7e7d5eeb39910d |
| Source note | uspto-grants-1977_10 |