Hydrochloric Acid → HCID 21404569, compound

Participants

Reaction Steps

A suspension of 3.0 g. (10.48 mmoles) of 6-[m-(diethylamino)phenyl]-1,2-dihydro-2-oxonicotinic acid in 50 ml. dichloromethane under nitrogen is treated with 0.85 ml. (11.54 mmoles) of thionyl chloride. Solution occurred at once and in about 15 minutes a solid started to appear. The suspension is allowed to stire at room temperature overnight. The solid 6-[m-(diethylamino)-phenyl]-1,2-dihydro-2-oxonicotinyl chloride, hydrochloride is collected and washed with dichloromethane. There is obtained 3.28 g. of the acid chloride, hydrochloride.

Provenance & Evidence