Thionyl Chloride → HCID 21404535, compound

HRID 972693Notes

Reaction equation

HRID 972693 reaction equation
[N+:1]([C:4]1[CH:5]=[C:6]([C:10]2[NH:11][C:12](=[O:19])[C:13](=[CH:17][CH:18]=2)[C:14](O)=O)[CH:7]=[CH:8][CH:9]=1)([O-:3])=[O:2].S(Cl)([Cl:22])=O>>[N+:1]([C:4]1[CH:5]=[C:6]([C:10]2[NH:11][C:12](=[O:19])[C:13](=[CH:17][CH:18]=2)[CH2:14][Cl:22])[CH:7]=[CH:8][CH:9]=1)([O-:3])=[O:2]

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 21404588HCID 21404588, compound

Product 1

HCID 21404535HCID 21404535, compound

Procedure

A 5 g. sample of 6-(m-nitrophenyl)-1,2-dihydro-2-oxonicotinic acid is suspended in 100 ml. thionyl chloride and stirred at room temperature overnight. The product 6-(m-nitrophenyl)-1,2-dihydro-2-oxonicotinyl chloride is carefully filtered off and washed with hexane and used directly in the preparation of compounds of the present invention.

Workup

  1. filtrationThe product 6-(m-nitrophenyl)-1,2-dihydro-2-oxonicotinyl chloride is carefully filtered off
  2. washwashed with hexane
  3. customused directly in the preparation of compounds of the present invention

Sources & evidence

ORD record
ord-da31680276324b0182c23582d5571c05
Source dataset
uspto-grants-1977_10
Patent number
US04053470

Reaction notes

Loading…