Thionyl Chloride → HCID 21404592, compound

HRID 972695Notes

Reaction equation

HRID 972695 reaction equation
[N:1]1([C:7]2[CH:8]=[C:9]([C:13]3[NH:14][C:15](=[O:22])[C:16](=[CH:20][CH:21]=3)[C:17](O)=O)[CH:10]=[CH:11][CH:12]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.S(Cl)([Cl:25])=O>>[ClH:25].[N:1]1([C:7]2[CH:8]=[C:9]([C:13]3[NH:14][C:15](=[O:22])[C:16](=[CH:20][CH:21]=3)[CH2:17][Cl:25])[CH:10]=[CH:11][CH:12]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 21404557HCID 21404557, compound

Product 1

HCID 21404592HCID 21404592, compound

Procedure

6-(m-Piperidinylphenyl)-1,2-dihydro-2-oxonicotinic acid, 5.22 g. (0.0165 mole) is added to 100 ml. of thionyl chloride and the mixture is stirred overnight at room temperature. The solid 6-(m-piperidinylphenyl)-1,2-dihydro-2-oxonicotinyl chloride hydrochloride is separated by filtration, washed three times with 100 ml. of hexane and dried over phosphorous pentoxide in vacuo. The product may be used directly in the next step.

Workup

  1. addition(0.0165 mole) is added to 100 ml
  2. customThe solid 6-(m-piperidinylphenyl)-1,2-dihydro-2-oxonicotinyl chloride hydrochloride is separated by filtration
  3. washwashed three times with 100 ml
  4. dry with materialof hexane and dried over phosphorous pentoxide in vacuo

Sources & evidence

ORD record
ord-fd35228fba05433aa9fceb4312cf09f8
Source dataset
uspto-grants-1977_10
Patent number
US04053470

Reaction notes

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