Hydrazine → 2-Chloro-4-hydrazino-6,7-dimethoxyquinazoline

Participants

Reaction Steps

To a solution of 20.8 g. of 2,4-dichloro-6,7-dimethoxyquinazoline in 400 ml. of methylene chloride is added dropwise 20 g. of hydrazine while maintaining the temperature below 30° C. with cooling. The resulting mixture was stirred for 45 minutes and then allowed to stand overnight at a temperature of 0° C. The mixture is then filtered and the solids washed first with water and then with methanol. The resulting solid material is then taken up in ice-water and stirred for 20 minutes. The mixture is then filtered and the resulting solid is recrystallized from methanol/methylene chloride to obtain 6,7-dimethoxy-2-chloro-4-hydrazino-quinazoline, m.p. 312°-315° C. (decomp.).

Provenance & Evidence