反应详情

To 65 ml. of allyl alcohol cooled to room temperature is added 2.8 g. of sodiuom followed by addition of an additional 120 ml. of allyl alcohol. To the resulting mixture at room temperature is added 15.0 g. of 5-chloro-8,9-dimethoxy-1,2,4-triazolo[4,3-c]quinazoline. The resulting precipitate is filtered off, washed with diethyl ether, dissolved in methylene chloride, washed with water, dried and evaporated in vacuo to dryness. The residue is twice crystallized from ethanol after treatment with charcoal to obtain 5-allyloxy-8,9-dimethoxy-1,2,4-triazolo[1,5-c]quinazoline, m.p. 189°-191° C.

1. additionis added 2.8 g
2. additionof sodiuom followed by addition of an additional 120 ml
3. additionTo the resulting mixture at room temperature is added 15.0 g
4. filtrationThe resulting precipitate is filtered off
5. washwashed with diethyl ether
6. dissolutiondissolved in methylene chloride
7. washwashed with water
8. customdried
9. customevaporated in vacuo to dryness
10. customThe residue is twice crystallized from ethanol after treatment with charcoal