反应详情

A mixture of 10.0 g. of 5-chloro-8,9-dimethoxy-1,2,4-triazolo[4,3-c]quinazoline, 38.8 g. of morpholine and 100 ml. of ethanol is refluxed for 1.5 hours and the resulting mixture evaporated in vacuo to dryness. The residue is taken up with ethanol and diethyl ether and filtered. The resulting solid is then recrystallized from benzene, filtered, washed with diethyl ether, recrystallized from ethanol and dried in a high vacuum to obtain 5-morpholino-8,9-dimethoxy-1,2,4-triazolo[4,3-c]quinazoline, m.p. 216°-218° C.

1. additionA mixture of 10.0 g
2. customthe resulting mixture evaporated in vacuo to dryness
3. filtrationfiltered
4. customThe resulting solid is then recrystallized from benzene
5. filtrationfiltered
6. washwashed with diethyl ether
7. customrecrystallized from ethanol
8. customdried in a high vacuum