Acetic Acid → HCID 178486881, compound

HRID 972717Notes

Reaction equation

HRID 972717 reaction equation
Cl[C:2]1[N:11]2[CH:12]=[N:13][N:14]=[C:10]2[C:9]2[CH:8]=[C:7]([O:15][CH3:16])[C:6]([O:17][CH3:18])=[CH:5][C:4]=2[N:3]=1.C(O)(=[O:21])C>>[CH3:18][O:17][C:6]1[C:7]([O:15][CH3:16])=[CH:8][C:9]2[C:4]([CH:5]=1)=[N:3][C:2](=[O:21])[N:14]1[NH:13][CH:12]=[N:11][C:10]=21

Participants

3

Reactant 2

HCID 176Acetic AcidHCID 214051435-Chloro-8,9-dimethoxy-1,2,4-triazolo[4,3-c]quinazoline

Product 1

HCID 178486881HCID 178486881, compound

Procedure

500 mg of 5-chloro-8,9-Dimethoxy-1,2,4-triazolo-[4,3-c]quinazoline is refluxed with 50 ml glacial acetic acid for 1 hour. The mixture is then evaporated in vacuo to dryness. The residue is treated with water/methylene chloride/diethyl ether and the solid material which is, 8,9-Dimethoxy-1,2,4-triazolo-[1,5-c]quinazoline-5-one is filtered off, washed well with water, then diethyl ether and dried, m.p. 320°-325° C.

Workup

  1. customThe mixture is then evaporated in vacuo to dryness
  2. additionThe residue is treated with water/methylene chloride/diethyl ether
  3. filtration8,9-Dimethoxy-1,2,4-triazolo-[1,5-c]quinazoline-5-one is filtered off
  4. washwashed well with water
  5. dry with materialdiethyl ether and dried

Sources & evidence

ORD record
ord-a873c846a1934d2899e7c73d965f46d6
Source dataset
uspto-grants-1977_10
Patent number
US04053600

Reaction notes

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