Ammonia → HCID 12393829, compound

Participants

Reaction Steps

The crude 1-(3-piperidinopropyl)-2-indanol (~ 0.2 M) is dissolved in 300 ml ether and added to 2 liters liquid ammonia. Lithium ribbon (50 g) is added in small portions over a period of 30 minutes. After stirring 11/2 hours, absolute ethanol is added dropwise until the color is discharged (~ 1 liter added over a period of 4 hours). The ammonia is allowed to evaporate and the residue is then diluted to 4 liters with water; two ether extracts yield 62 g of crude diene which becomes partially crystalline on standing.

Provenance & Evidence