HuagongsheHuagongshe Chemistry Print Report · For research reference only
(S)-2-phenyl-3-tert-butyl-5-hydroxymethyloxazolidine → 2-(3-tert. Butylamino-2-acetoxypropoxy)-3-cyanopyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (S)-2-phenyl-3-tert-butyl-5-hydroxymethyloxazolidine | HCID 12296652 | — |
| Reactant | 2-Phenyl-3-isopropyl-5-hydroxymethyloxazolidine | HCID 12566198 | — |
| Reactant | 3-Isopropyl-5-hydroxymethyloxazolidine | HCID 21321287 | — |
| Reactant | (S)-2-methyl-3-sec. butyl-5-hydroxymethyloxazolidine | HCID 131710938 | — |
| Product | 2-(3-tert. Butylamino-2-acetoxypropoxy)-3-cyanopyridine | HCID 131710937 | — |
Reaction Steps
Isopropyl or sec. butyl amino analogues of the compounds of the above examples are prepared by substituting suitable oxazolidines e.g. 2-phenyl-3-isopropyl-5-hydroxymethyloxazolidine, (S)-2-methyl-3-sec. butyl-5-hydroxymethyloxazolidine, 3-isopropyl-5-hydroxymethyloxazolidine for the (S)-2-phenyl-3-tert. butyl-5-hydroxymethyloxazolidine reactant.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04053605 |
| Source dataset | uspto-grants-1977_10 |
| ORD ID | ord-ea3ecd972f3c4c1cb8daf722628683da |
| Source note | uspto-grants-1977_10 |