HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanolamine → N-(2-Hydroxyethyl)-2-methyl-5-nitropyridine-3-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanolamine | HCID 700 | — |
| Reactant | Ethyl 2-methyl-5-nitronicotinate | HCID 287239 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | N-(2-Hydroxyethyl)-2-methyl-5-nitropyridine-3-carboxamide | HCID 54034267 | — |
Reaction Steps
A mixture of ethyl 2-methyl-5-nitronicotinate (1 g.) and 2-aminoethanol (4 ml.) in ethanol (5ml.) was stirred at room temperature for 16 hours. The solvent was distilled off, the residue was purified by silica gel chromatography and recrystallized from ethyl acetate n-hexane to give the desired yellow crystals. mp 144° - 145° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04053608 |
| Source dataset | uspto-grants-1977_10 |
| ORD ID | ord-e50f24c5f5de465a89c287c68e8b8281 |
| Source note | uspto-grants-1977_10 |