HuagongsheHuagongshe Chemistry Print Report · For research reference only
Formaldehyde → N-(Hydroxymethyl)-5-nitropyridine-3-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Formaldehyde | HCID 712 | — |
| Reactant | 5-Nitropyridine-3-carboxamide | HCID 13292025 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | N-(Hydroxymethyl)-5-nitropyridine-3-carboxamide | HCID 21405355 | — |
Reaction Steps
A solution of 1.0 g of 5-nitronicotinamide and 2ml of 37% formalin in 3 ml of dimethylformamide was stirred at 100° C. for 2 hours. After cooling, ice-water was added and the mixture was extracted with ethyl acetate. The extract was chromatographed over silica gel and recrystallized from ethanol to give 0.6 g of the desired product. mp 145° - 146° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04053608 |
| Source dataset | uspto-grants-1977_10 |
| ORD ID | ord-3527936925d74924bdece9eafe9dd2dd |
| Source note | uspto-grants-1977_10 |