HuagongsheHuagongshe Chemistry Print Report · For research reference only
Butyl isocyanate → N-(Butylcarbamoyl)-2-methyl-5-nitropyridine-3-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Butyl isocyanate | HCID 8110 | — |
| Reactant | 2-Methyl-5-nitropyridine-3-carboxamide | HCID 21405270 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | N-(Butylcarbamoyl)-2-methyl-5-nitropyridine-3-carboxamide | HCID 53864046 | 43.1% |
Reaction Steps
A mixture of 0.9 g of 2-methyl-5-nitronicotinamide and 0.9 g of n-butylisocyanate in 40 ml of anhydrous toluene was refluxed for 18 hours. Unreacted nicotinamide (0.2 g) was filtered off and the filtrate was chromatographed over silica gel to give 0.6 g of the desired product. mp 111° - 112° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04053608 |
| Source dataset | uspto-grants-1977_10 |
| ORD ID | ord-6298fcc7effe433b9f5a581fd10e12fe |
| Source note | uspto-grants-1977_10 |