tert-Butyl carbazate → HCID 21405185, compound

HRID 972779Notes

Reaction equation

[C:1]([NH:5][CH2:6][CH:7]([OH:25])[CH2:8][O:9][C:10]1[CH:15]=[C:14]([O:16][CH3:17])[CH:13]=[CH:12][C:11]=1[C:18]1[N:19]=[N:20][C:21](Cl)=[CH:22][CH:23]=1)([CH3:4])([CH3:3])[CH3:2].[C:26]([O:30][C:31]([CH3:34])([CH3:33])[CH3:32])(=[O:29])[NH:27][NH2:28].CN(C)C1C2C(=CC=CC=2N(C)C)C=CC=1>>[C:1]([NH:5][CH2:6][CH:7]([OH:25])[CH2:8][O:9][C:10]1[CH:15]=[C:14]([O:16][CH3:17])[CH:13]=[CH:12][C:11]=1[C:18]1[N:19]=[N:20][C:21]([NH:28][NH:27][C:26]([O:30][C:31]([CH3:34])([CH3:33])[CH3:32])=[O:29])=[CH:22][CH:23]=1)([CH3:4])([CH3:3])[CH3:2]

Participants

Reactant 3

HCID 70091tert-Butyl carbazate

HCID 88675Proton sponge

HCID 20309446HCID 20309446, compound

Product 1

HCID 21405185HCID 21405185, compound

Procedure

i. A mixture of 3-[2-(3-t-butylamino-2-hydroxypropoxy)-4-methoxyphenyl]-6-chloro-pyridazine, t-butyl carbazate and 1,8-bis-(dimethylamino)naphthalene was heated for 2 hours to give 3-[2-(3-t-butylamino-2-hydroxypropoxy)-4-methoxyphenyl]-6-(2-t-butyloxycarbonylhydrazino)pyridazine.

Workup

temperaturewas heated for 2 hours

Sources & evidence

ORD record: ord-de2a70eda5b54a55909f1dcb2ffaa912
Source dataset: uspto-grants-1977_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04053601

Reaction notes

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