反应详情

4.69 Grams of 4-amino-1-n-butylpiperidine in 100 milliliters of chloroform were added to a suspension of 5.79 grams of 4-nitrophthalic anhydride in 75 milliliters of chloroform and the solution was evaporated to dryness. 40 Milliliters of acetic anhydride were added and the mixture was then heated on a steam bath for half an hour. The excess acetic anhydride was evaporated off and the residue dissolved in 40 milliliters of methanol and ethereal hydrogen chloride was added to give a solid which was collected giving 2.50 grams of the title compound as the monohydrochloride.

1. customthe solution was evaporated to dryness
2. addition40 Milliliters of acetic anhydride were added
3. temperaturethe mixture was then heated on a steam bath for half an hour
4. customThe excess acetic anhydride was evaporated off
5. dissolutionthe residue dissolved in 40 milliliters of methanol
6. additionethereal hydrogen chloride was added
7. customto give a solid which
8. customwas collected