Acetic acid ethanol → HCID 21405550, compound

Participants

Reaction Steps

A solution of 1.7 grams (0.005 mole) of 1-ethyl-4-(4-nitrophthalimido)piperidine hydrochloride in 60 milliliters of glacial acetic acid was hydrogenated over 0.1 grams of 10% palladium on carbon catalyst at 50 p.s.i. After the theoretical uptake of hydrogen, a little acetic acid/ethanol mixture was added to dissolve precipitated solid; the catalyst was filtered off, the solvents evaporated and the residue trituated with ether to give a yellow solid. Recrystallisation from methanol gave 1.18 grams of 4-(4-aminophthalimido)-1-ethylpiperidine hydrochloride hydrate, m.p. 254° C(decomp).

Provenance & Evidence