Ethyl 5-(2-propyl-5-thiazolyl)2,4-pentadienoate → 2-Propyl-5-thiazole-pentanoic acid

HRID 972838Notes

Reaction equation

HRID 972838 reaction equation
[CH2:1]([C:4]1[S:5][C:6]([CH:9]=[CH:10][CH:11]=[CH:12][C:13]([O:15]CC)=[O:14])=[CH:7][N:8]=1)[CH2:2][CH3:3].[H][H]>>[CH2:1]([C:4]1[S:5][C:6]([CH2:9][CH2:10][CH2:11][CH2:12][C:13]([OH:15])=[O:14])=[CH:7][N:8]=1)[CH2:2][CH3:3]

Participants

3

Reactant 2

HCID 54337588Ethyl 5-(2-propyl-5-thiazolyl)2,4-pentadienoateHCID 178418361HCID 178418361, compound

Product 1

HCID 214055872-Propyl-5-thiazole-pentanoic acid

Procedure

Using the procedure of Example 10, ethyl 5-(2-propyl-5-thiazolyl)2,4-pentadienoate was reacted with hydrogen in the presence of activated carbon containing 10% palladium and the resulting product was saponified to obtain 2-propyl-5-thiazole-pentanoic acid. The latter product was reacted with α,β-ethanedisulfonic acid to obtain the hemi-α,β-ethane disulfonate of 2-propyl-5-thiazole-pentanoic acid melting at 124°C.

Sources & evidence

ORD record
ord-e0ef3ecf46ab47c5815f51e44188846c
Source dataset
uspto-grants-1977_10
Patent number
US04053618

Reaction notes

Loading…