Acetic Anhydride → HCID 70601935, compound

HRID 972856Notes

Reaction equation

HRID 972856 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6]C(CO)=[CH:4][N:3]=1.[C:10]([O:13][C:14](=O)[CH3:15])(=[O:12])[CH3:11]>N1C=CC=CC=1>[CH3:1][C:2]1[C:7]([CH3:6])=[CH:15][C:14]([O:13][C:10](=[O:12])[CH3:11])=[CH:4][N:3]=1

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 11228788(6-Methylpyridin-3-yl)methanol

Product 1

HCID 70601935HCID 70601935, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

2-Methyl-5-hydroxymethylpyridine (0.1 mole) is stirred in pyridine (50 ml.) with acetic anhydride (0.15 mole) at room temperature overnight. The mixture is concentrated to dryness, and the residue is dissolved in 70 ml. of water and extracted with 3 × 25 ml. of chloroform. After drying over magnesium sulfate, the chloroform is concentrated to dryness to give 2-methyl-5-acetoxy-methylpyridine.

Workup

  1. concentrationThe mixture is concentrated to dryness
  2. dissolutionthe residue is dissolved in 70 ml
  3. extractionof water and extracted with 3 × 25 ml
  4. dry with materialAfter drying over magnesium sulfate
  5. concentrationthe chloroform is concentrated to dryness

Sources & evidence

ORD record
ord-3acc82406708415e8c2256d0e6187861
Source dataset
uspto-grants-1977_10
Patent number
US04053606

Reaction notes

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