反应详情

To a stirred solution of 65 g. of 2-methyl-3-hydroxy-4-chloromethyl-5-vinylpyridine in 1 liter of ethanol under nitrogen there was added 96 g. of potassium thiobenzoate in 200 ml. of water over 30 minutes. After 1 hour, the ethanol was evaporated at 40° C. and the aqueous solution was extracted with 4 × 300 ml. of ethyl acetate. The extract was washed with 1 × 75 ml. of water, dried over magnesium sulfate and concentrated to dryness to give 2-methyl-3-hydroxy-4-benzoylthiomethyl-5-vinylpyridine.

1. customthe ethanol was evaporated at 40° C.
2. extractionthe aqueous solution was extracted with 4 × 300 ml
3. washThe extract was washed with 1 × 75 ml
4. dry with materialof water, dried over magnesium sulfate
5. concentrationconcentrated to dryness